Detailed information of TA system TA287629

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2624576..2624912
• Replicon: chromosome
• Accession: NZ_LR134312
• Organism: Enterococcus faecalis strain NCTC8745

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: EL135_RS13080
• Protein ID: WP_002381035.1
• Coordinates: 2624576..2624719 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2624863..2624912 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL135_RS13055	2620675..2621304	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
EL135_RS13065	2621997..2623613	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
EL135_RS13070	2623943..2624086	+	144	WP_002392818.1	putative holin-like toxin	-
EL135_RS13075	2624205..2624345	+	141	WP_073340360.1	putative holin-like toxin	-
EL135_RS13080	2624576..2624719	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2624863..2624912	+	50	-	-	Antitoxin
EL135_RS13085	2624914..2627910	-	2997	WP_002385134.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T287629 WP_002381035.1 NZ_LR134312:2624576-2624719 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 50 bp

>AT287629 NZ_LR134312:2624863-2624912 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin