Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2624205..2624476 Replicon chromosome
Accession NZ_LR134312
Organism Enterococcus faecalis strain NCTC8745

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag EL135_RS13075 Protein ID WP_073340360.1
Coordinates 2624205..2624345 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2624278..2624476 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL135_RS13050 2619419..2620411 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
EL135_RS13055 2620675..2621304 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
EL135_RS13065 2621997..2623613 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
EL135_RS13070 2623943..2624086 + 144 WP_002392818.1 putative holin-like toxin -
EL135_RS13075 2624205..2624345 + 141 WP_073340360.1 putative holin-like toxin Toxin
- 2624278..2624476 - 199 - - Antitoxin
EL135_RS13080 2624576..2624719 + 144 WP_002381035.1 putative holin-like toxin -
EL135_RS13085 2624914..2627910 - 2997 WP_002385134.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T287623 WP_073340360.1 NZ_LR134312:2624205-2624345 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

Antitoxin


Download         Length: 199 bp

>AT287623 NZ_LR134312:c2624476-2624278 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References