Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2545982..2546381 Replicon chromosome
Accession NZ_LR134312
Organism Enterococcus faecalis strain NCTC8745

Toxin (Protein)


Gene name txpA Uniprot ID A0A4U4MH53
Locus tag EL135_RS12700 Protein ID WP_073340330.1
Coordinates 2545982..2546134 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2546238..2546381 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL135_RS12680 2541276..2544020 + 2745 WP_025189125.1 glycoside hydrolase family 65 protein -
EL135_RS12685 2544035..2544685 + 651 WP_010816064.1 beta-phosphoglucomutase -
EL135_RS12690 2545148..2545741 + 594 WP_002389391.1 hypothetical protein -
EL135_RS12700 2545982..2546134 - 153 WP_073340330.1 putative holin-like toxin Toxin
- 2546238..2546381 + 144 - - Antitoxin
EL135_RS12705 2546811..2547005 + 195 Protein_2348 CPBP family intramembrane metalloprotease -
EL135_RS12710 2547058..2548029 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
EL135_RS12715 2548204..2548641 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
EL135_RS12720 2548774..2549328 - 555 WP_002354869.1 septum formation protein Maf -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(17-50)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5665.96 Da        Isoelectric Point: 11.0942

>T287616 WP_073340330.1 NZ_LR134312:c2546134-2545982 [Enterococcus faecalis]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 153 bp

Antitoxin


Download         Length: 144 bp

>AT287616 NZ_LR134312:2546238-2546381 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U4MH53

Antitoxin

Download structure file

References