Detailed information of TA system TA287612

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2476346..2476598
• Replicon: chromosome
• Accession: NZ_LR134312
• Organism: Enterococcus faecalis strain NCTC8745

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EL135_RS12365
• Protein ID: WP_002393909.1
• Coordinates: 2476470..2476598 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2476346..2476525 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL135_RS12335	2471562..2472515	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
EL135_RS12340	2472554..2473309	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
EL135_RS12345	2473306..2474271	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
EL135_RS12350	2474268..2475215	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
EL135_RS12355	2475400..2475852	+	453	WP_002354958.1	YueI family protein	-
EL135_RS12360	2476037..2476164	-	128	Protein_2283	putative holin-like toxin	-
-	2476346..2476525	+	180	-	-	Antitoxin
EL135_RS12365	2476470..2476598	-	129	WP_002393909.1	hypothetical protein	Toxin
EL135_RS12370	2476761..2479031	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
EL135_RS12375	2479202..2479702	+	501	WP_002354954.1	cysteine hydrolase	-
EL135_RS12380	2480249..2481145	+	897	WP_002354953.1	YitT family protein	-
EL135_RS12385	2481196..2481594	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T287612 WP_002393909.1 NZ_LR134312:c2476598-2476470 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

Antitoxin

Nucleotide

• Length: 180 bp

>AT287612 NZ_LR134312:2476346-2476525 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin