Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4650799..4651401 Replicon chromosome
Accession NZ_LR134311
Organism Escherichia coli strain NCTC9113

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag EL186_RS22475 Protein ID WP_000897305.1
Coordinates 4651090..4651401 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL186_RS22470 Protein ID WP_000356397.1
Coordinates 4650799..4651089 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL186_RS22445 4646725..4647627 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
EL186_RS22450 4647624..4648259 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
EL186_RS22455 4648256..4649185 + 930 WP_000027706.1 formate dehydrogenase accessory protein FdhE -
EL186_RS22460 4649515..4649757 - 243 WP_001087409.1 hypothetical protein -
EL186_RS22465 4649976..4650194 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
EL186_RS22470 4650799..4651089 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EL186_RS22475 4651090..4651401 - 312 WP_000897305.1 hypothetical protein Toxin
EL186_RS22480 4651630..4652538 + 909 WP_001162704.1 alpha/beta hydrolase -
EL186_RS22485 4652602..4653543 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
EL186_RS22490 4653588..4654025 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL186_RS22495 4654022..4654894 - 873 WP_000920762.1 virulence factor BrkB family protein -
EL186_RS22500 4654888..4655487 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T287610 WP_000897305.1 NZ_LR134311:c4651401-4651090 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT287610 WP_000356397.1 NZ_LR134311:c4651089-4650799 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References