Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3788647..3789188 Replicon chromosome
Accession NZ_LR134311
Organism Escherichia coli strain NCTC9113

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag EL186_RS18440 Protein ID WP_000615976.1
Coordinates 3788910..3789188 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EL186_RS18435 Protein ID WP_000729704.1
Coordinates 3788647..3788907 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL186_RS18410 3784430..3785215 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
EL186_RS18415 3785187..3786899 + 1713 Protein_3549 flagellar biosynthesis protein FlhA -
EL186_RS18420 3787004..3787282 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EL186_RS18425 3787275..3787631 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
EL186_RS18430 3787688..3788461 - 774 WP_000543895.1 C40 family peptidase -
EL186_RS18435 3788647..3788907 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL186_RS18440 3788910..3789188 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL186_RS18445 3789344..3790084 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL186_RS18450 3790055..3790822 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL186_RS18455 3791028..3791606 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3787275..3799974 12699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T287607 WP_000615976.1 NZ_LR134311:3788910-3789188 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT287607 WP_000729704.1 NZ_LR134311:3788647-3788907 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References