Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1897371..1897873 Replicon chromosome
Accession NZ_LR134311
Organism Escherichia coli strain NCTC9113

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL186_RS09145 Protein ID WP_000767829.1
Coordinates 1897619..1897873 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL186_RS09140 Protein ID WP_001259255.1
Coordinates 1897371..1897622 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL186_RS09115 1892549..1893616 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL186_RS09120 1893616..1894686 - 1071 WP_000108962.1 histidinol-phosphate transaminase -
EL186_RS09125 1894683..1895987 - 1305 WP_001369878.1 histidinol dehydrogenase -
EL186_RS09130 1895993..1896892 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL186_RS09135 1897038..1897088 - 51 WP_001364200.1 his operon leader peptide -
EL186_RS09140 1897371..1897622 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL186_RS09145 1897619..1897873 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL186_RS09150 1897956..1898780 + 825 WP_000754749.1 SDR family oxidoreductase -
EL186_RS09155 1898826..1899755 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL186_RS09160 1899970..1900032 + 63 WP_010723108.1 membrane protein YoeI -
EL186_RS09165 1900022..1901380 + 1359 WP_049033951.1 putrescine/proton symporter PlaP -
EL186_RS09170 1901559..1902617 + 1059 WP_000492346.1 transport protein YeeE -
EL186_RS09175 1902631..1902858 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287598 WP_000767829.1 NZ_LR134311:1897619-1897873 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287598 WP_001259255.1 NZ_LR134311:1897371-1897622 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References