287590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5801969..5802564 Replicon chromosome
Accession NZ_LR134309
Organism Pseudomonas aeruginosa strain NCTC12903

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EL344_RS28180 Protein ID WP_003117425.1
Coordinates 5802286..5802564 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL344_RS28175 Protein ID WP_003099268.1
Coordinates 5801969..5802274 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL344_RS28140 5797422..5797712 - 291 WP_023083237.1 DUF5447 family protein -
EL344_RS28150 5797924..5798196 - 273 WP_003115921.1 hypothetical protein -
EL344_RS28155 5798306..5798572 + 267 WP_016852153.1 hypothetical protein -
EL344_RS28160 5798695..5799540 + 846 WP_196645791.1 helix-turn-helix domain-containing protein -
EL344_RS28165 5799515..5801053 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
EL344_RS28170 5801065..5801592 - 528 WP_071535723.1 AAA family ATPase -
EL344_RS28175 5801969..5802274 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
EL344_RS28180 5802286..5802564 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL344_RS28190 5802893..5805121 + 2229 WP_003099265.1 TonB-dependent receptor -
EL344_RS28195 5805191..5805838 - 648 WP_003095021.1 carbonate dehydratase -
EL344_RS28200 5805900..5807138 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T287590 WP_003117425.1 NZ_LR134309:c5802564-5802286 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT287590 WP_003099268.1 NZ_LR134309:c5802274-5801969 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References