Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2223438..2223961 Replicon chromosome
Accession NZ_LR134305
Organism Staphylococcus aureus strain NCTC1803

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EL119_RS11735 Protein ID WP_000074048.1
Coordinates 2223438..2223704 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag EL119_RS11740 Protein ID WP_000587617.1
Coordinates 2223704..2223961 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL119_RS11715 2218648..2219835 - 1188 WP_000026189.1 MFS transporter -
EL119_RS11720 2220230..2221006 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
EL119_RS11725 2220999..2221661 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
EL119_RS11730 2222006..2223082 - 1077 WP_001076674.1 M42 family metallopeptidase -
EL119_RS11735 2223438..2223704 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EL119_RS11740 2223704..2223961 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL119_RS11750 2224322..2224777 + 456 WP_000732082.1 DUF1307 domain-containing protein -
EL119_RS11755 2224945..2226522 - 1578 WP_065315873.1 FMN-binding glutamate synthase family protein -
EL119_RS11760 2226716..2227465 + 750 WP_000072455.1 CPBP family intramembrane metalloprotease -
EL119_RS11765 2227689..2228882 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T287562 WP_000074048.1 NZ_LR134305:c2223704-2223438 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT287562 WP_000587617.1 NZ_LR134305:c2223961-2223704 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References