Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2164774..2165291 Replicon chromosome
Accession NZ_LR134305
Organism Staphylococcus aureus strain NCTC1803

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EL119_RS11425 Protein ID WP_000375483.1
Coordinates 2164774..2165040 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EL119_RS11430 Protein ID WP_000584499.1
Coordinates 2165040..2165291 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL119_RS11400 2159925..2160461 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
EL119_RS11405 2160981..2161805 - 825 WP_000594631.1 formate/nitrite transporter family protein -
EL119_RS11410 2162008..2162190 - 183 WP_000079140.1 hypothetical protein -
EL119_RS11415 2162277..2162744 - 468 WP_000153340.1 SRPBCC domain-containing protein -
EL119_RS11420 2162930..2164480 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EL119_RS11425 2164774..2165040 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
EL119_RS11430 2165040..2165291 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL119_RS11435 2165455..2165555 - 101 Protein_2115 hypothetical protein -
EL119_RS11440 2165562..2166161 - 600 WP_000162810.1 DsbA family protein -
EL119_RS11445 2166180..2166542 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EL119_RS11450 2166797..2168047 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
EL119_RS11455 2168140..2168871 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EL119_RS11460 2168868..2169587 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T287560 WP_000375483.1 NZ_LR134305:c2165040-2164774 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT287560 WP_000584499.1 NZ_LR134305:c2165291-2165040 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References