Detailed information of TA system TA287550

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 57001..57519
• Replicon: chromosome
• Accession: NZ_LR134305
• Organism: Staphylococcus aureus strain NCTC1803

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: EL119_RS00400
• Protein ID: WP_000448764.1
• Coordinates: 57217..57519 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	57001..57137 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL119_RS00360	52095..52385	+	291	WP_000179860.1	hypothetical protein	-
EL119_RS00365	52401..54311	+	1911	WP_000429563.1	hypothetical protein	-
EL119_RS00370	54311..55777	+	1467	WP_000067157.1	BppU family phage baseplate upper protein	-
EL119_RS00375	55777..56166	+	390	WP_001166604.1	DUF2977 domain-containing protein	-
EL119_RS00380	56159..56323	+	165	WP_000916020.1	XkdX family protein	-
EL119_RS00385	56369..56668	+	300	WP_000466773.1	DUF2951 family protein	-
EL119_RS14640	56820..57009	+	190	Protein_75	putative holin-like toxin	-
-	57001..57137	-	137	NuclAT_0	-	Antitoxin
-	57001..57137	-	137	NuclAT_0	-	Antitoxin
-	57001..57137	-	137	NuclAT_0	-	Antitoxin
-	57001..57137	-	137	NuclAT_0	-	Antitoxin
EL119_RS00395	57056..57166	-	111	WP_070003492.1	hypothetical protein	-
EL119_RS00400	57217..57519	+	303	WP_000448764.1	phage holin	Toxin
EL119_RS00405	57531..58985	+	1455	WP_000930278.1	N-acetylmuramoyl-L-alanine amidase	-
EL119_RS14720	59808..59921	-	114	Protein_79	amidase	-
EL119_RS00415	60499..60996	+	498	WP_001803960.1	hypothetical protein	-
EL119_RS00425	61556..62383	-	828	WP_000136028.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	14062..58985	44923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11230.99 Da
• Isoelectric Point: 9.6587

>T287550 WP_000448764.1 NZ_LR134305:57217-57519 [Staphylococcus aureus]
METKVITRYIVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTAYKDNPTSQEGRWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

Antitoxin

Nucleotide

• Length: 137 bp

>AT287550 NZ_LR134305:c57137-57001 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTGTAGTTAAAT
GAATTTATATAATCCTCTAACCATCGTACTCGTCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin