287549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2492936..2493459 Replicon chromosome
Accession NZ_LR134304
Organism Staphylococcus schweitzeri strain NCTC13712

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K4AFL7
Locus tag EL116_RS12355 Protein ID WP_047549951.1
Coordinates 2492936..2493202 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2K4AGF2
Locus tag EL116_RS12360 Protein ID WP_000587615.1
Coordinates 2493202..2493459 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL116_RS12335 2488338..2489525 - 1188 WP_047529796.1 MFS transporter -
EL116_RS12340 2489878..2490651 - 774 WP_047426423.1 iron export ABC transporter permease subunit FetB -
EL116_RS12345 2490644..2491306 - 663 WP_047549945.1 ATP-binding cassette domain-containing protein -
EL116_RS12350 2491547..2492623 - 1077 WP_047549948.1 M42 family metallopeptidase -
EL116_RS12355 2492936..2493202 - 267 WP_047549951.1 Txe/YoeB family addiction module toxin Toxin
EL116_RS12360 2493202..2493459 - 258 WP_000587615.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL116_RS12365 2493816..2494280 + 465 WP_047426431.1 DUF1307 domain-containing protein -
EL116_RS12370 2494448..2496025 - 1578 WP_047549954.1 FMN-binding glutamate synthase family protein -
EL116_RS12375 2496215..2496964 + 750 WP_047549957.1 hypothetical protein -
EL116_RS12380 2497188..2498381 - 1194 WP_006191034.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(27-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10647.20 Da        Isoelectric Point: 9.7239

>T287549 WP_047549951.1 NZ_LR134304:c2493202-2492936 [Staphylococcus schweitzeri]
MSNYTVKIKNSAKSDLKKIKHSYLKESFLEIVETLKNDPHKITQSFEKLEPKYLERYLRRINYQHRVVYTVDDQNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9746.68 Da        Isoelectric Point: 4.1111

>AT287549 WP_000587615.1 NZ_LR134304:c2493459-2493202 [Staphylococcus schweitzeri]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AFL7

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AGF2

References