Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2438690..2439207 Replicon chromosome
Accession NZ_LR134304
Organism Staphylococcus schweitzeri strain NCTC13712

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K4AFN5
Locus tag EL116_RS12105 Protein ID WP_047549868.1
Coordinates 2438690..2438956 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2K4AFP1
Locus tag EL116_RS12110 Protein ID WP_047549871.1
Coordinates 2438956..2439207 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL116_RS12080 2434115..2434651 - 537 WP_047549856.1 GNAT family N-acetyltransferase -
EL116_RS12085 2434890..2435714 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EL116_RS12090 2435930..2436115 - 186 WP_047425811.1 hypothetical protein -
EL116_RS12095 2436199..2436666 - 468 WP_047549859.1 SRPBCC domain-containing protein -
EL116_RS12100 2436851..2438398 - 1548 WP_047425807.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EL116_RS12105 2438690..2438956 - 267 WP_047549868.1 Txe/YoeB family addiction module toxin Toxin
EL116_RS12110 2438956..2439207 - 252 WP_047549871.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL116_RS12115 2439369..2439470 - 102 Protein_2282 hypothetical protein -
EL116_RS12120 2439477..2440076 - 600 WP_047549875.1 DsbA family protein -
EL116_RS12125 2440096..2440458 - 363 WP_047425801.1 DUF4467 domain-containing protein -
EL116_RS12130 2440712..2441962 + 1251 WP_047549878.1 aminoacyltransferase -
EL116_RS12135 2442057..2442788 - 732 WP_047529873.1 amino acid ABC transporter ATP-binding protein -
EL116_RS12140 2442785..2443504 - 720 WP_047425796.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10409.94 Da        Isoelectric Point: 10.0573

>T287547 WP_047549868.1 NZ_LR134304:c2438956-2438690 [Staphylococcus schweitzeri]
MTRLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDGNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9418.59 Da        Isoelectric Point: 4.4702

>AT287547 WP_047549871.1 NZ_LR134304:c2439207-2438956 [Staphylococcus schweitzeri]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
INV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AFN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AFP1

References