Detailed information of TA system TA287539

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 793486..794007
• Replicon: chromosome
• Accession: NZ_LR134304
• Organism: Staphylococcus schweitzeri strain NCTC13712

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A2K4AK13
• Locus tag: EL116_RS03855
• Protein ID: WP_047530997.1
• Coordinates: 793705..794007 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	793486..793625 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL116_RS03825	788719..789654	+	936	WP_047427095.1	thioredoxin-disulfide reductase	-
EL116_RS03830	790002..790913	+	912	WP_031787679.1	RNase adapter RapZ	-
EL116_RS03835	790910..791911	+	1002	WP_047551142.1	YvcK family protein	-
EL116_RS03840	792017..792961	+	945	WP_047427100.1	DNA-binding protein WhiA	-
EL116_RS03845	793318..793494	+	177	WP_011447039.1	putative holin-like toxin	-
-	793486..793625	-	140	NuclAT_0	-	Antitoxin
-	793486..793625	-	140	NuclAT_0	-	Antitoxin
-	793486..793625	-	140	NuclAT_0	-	Antitoxin
-	793486..793625	-	140	NuclAT_0	-	Antitoxin
EL116_RS03850	793547..793654	-	108	WP_047551145.1	hypothetical protein	-
EL116_RS03855	793705..794007	+	303	WP_047530997.1	phage holin	Toxin
EL116_RS03860	794056..794217	+	162	Protein_717	N-acetylmuramoyl-L-alanine amidase	-
EL116_RS03870	794587..795174	+	588	WP_001049165.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	-
EL116_RS03875	795353..796987	+	1635	WP_047551149.1	NAD-dependent malic enzyme	-
EL116_RS03880	797186..798088	-	903	WP_047551151.1	TIGR01777 family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11269.99 Da
• Isoelectric Point: 9.9519

>T287539 WP_047530997.1 NZ_LR134304:793705-794007 [Staphylococcus schweitzeri]
IDTKVISRYFVLILALGNQFLANKGISPIPVDDETISSIRFIVVAFCTNYKNNSISQEGKWANQKLKKYKAENKYRKATG
QVPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT287539 NZ_LR134304:c793625-793486 [Staphylococcus schweitzeri]
ATATATAGAAAAAGGGCAACATGCGCAAACACGTTACCCTAATGAACCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A2K4AK13

Antitoxin