Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4191613..4192200 Replicon chromosome
Accession NZ_LR134301
Organism Stenotrophomonas maltophilia strain NCTC13014

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EL200_RS19560 Protein ID WP_080354792.1
Coordinates 4191613..4191891 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL200_RS19565 Protein ID WP_049443949.1
Coordinates 4191901..4192200 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL200_RS19535 4186851..4187948 + 1098 WP_057501087.1 Fis family transcriptional regulator -
EL200_RS19540 4187985..4188467 - 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
EL200_RS19545 4188587..4189483 + 897 WP_049443945.1 DMT family transporter -
EL200_RS19550 4189683..4190690 + 1008 WP_057501086.1 methionine ABC transporter ATP-binding protein -
EL200_RS19555 4190687..4191376 + 690 WP_057501085.1 ABC transporter permease -
EL200_RS19560 4191613..4191891 + 279 WP_080354792.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL200_RS19565 4191901..4192200 + 300 WP_049443949.1 HigA family addiction module antidote protein Antitoxin
EL200_RS19570 4192241..4192843 - 603 WP_049443951.1 lipocalin family protein -
EL200_RS19575 4192972..4193298 + 327 WP_057501084.1 hypothetical protein -
EL200_RS19580 4193368..4195464 + 2097 WP_057501083.1 prolyl oligopeptidase family protein -
EL200_RS19585 4195631..4196818 - 1188 WP_057501082.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10685.19 Da        Isoelectric Point: 10.3074

>T287519 WP_080354792.1 NZ_LR134301:4191613-4191891 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCARAWRPIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRKGQYSLRINDQWRLCFTWTD
NGADAVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10876.54 Da        Isoelectric Point: 10.7753

>AT287519 WP_049443949.1 NZ_LR134301:4191901-4192200 [Stenotrophomonas maltophilia]
MKHPHNGMRAIHPGEILREEFLLPLALSVNALARALDVPATRLHAIVHGERGISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRNEIERRVQPRAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References