Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4601789..4602384 Replicon chromosome
Accession NZ_LR134300
Organism Pseudomonas fluorescens strain NCTC10783

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL286_RS21945 Protein ID WP_071535843.1
Coordinates 4602106..4602384 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL286_RS21940 Protein ID WP_003099268.1
Coordinates 4601789..4602094 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL286_RS21915 4597639..4597845 - 207 WP_034076322.1 AlpA family transcriptional regulator -
EL286_RS21920 4597900..4599141 - 1242 WP_172616480.1 hypothetical protein -
EL286_RS21925 4599245..4600057 + 813 WP_126450760.1 hypothetical protein -
EL286_RS21930 4600923..4601120 + 198 WP_023436186.1 TonB-dependent receptor -
EL286_RS21940 4601789..4602094 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
EL286_RS21945 4602106..4602384 - 279 WP_071535843.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL286_RS21955 4602713..4604941 + 2229 WP_126450762.1 TonB-dependent receptor -
EL286_RS21960 4605011..4605658 - 648 WP_003095021.1 carbonate dehydratase -
EL286_RS21965 4605720..4606958 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10674.25 Da        Isoelectric Point: 7.8937

>T287517 WP_071535843.1 NZ_LR134300:c4602384-4602106 [Pseudomonas fluorescens]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT287517 WP_003099268.1 NZ_LR134300:c4602094-4601789 [Pseudomonas fluorescens]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References