Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 549801..550533 Replicon chromosome
Accession NZ_LR134298
Organism Pasteurella multocida subsp. gallicida strain NCTC10204

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag EL104_RS02665 Protein ID WP_005725755.1
Coordinates 549801..550127 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL104_RS02670 Protein ID WP_005757699.1
Coordinates 550207..550533 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL104_RS02640 545118..545804 + 687 WP_005757690.1 hypothetical protein -
EL104_RS02645 545858..547387 - 1530 WP_074866885.1 YifB family Mg chelatase-like AAA ATPase -
EL104_RS02650 547495..548112 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
EL104_RS02655 548223..549092 + 870 WP_010907199.1 VirK/YbjX family protein -
EL104_RS02660 549167..549643 - 477 WP_005755093.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL104_RS02665 549801..550127 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL104_RS02670 550207..550533 + 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
EL104_RS02675 550587..552107 - 1521 WP_059245887.1 DUF560 domain-containing protein -
EL104_RS02680 552166..552768 - 603 WP_005755098.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
EL104_RS02685 552855..553805 - 951 WP_126358541.1 hypothetical protein -
EL104_RS02690 554041..555060 - 1020 WP_074866879.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T287502 WP_005725755.1 NZ_LR134298:549801-550127 [Pasteurella multocida subsp. gallicida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT287502 WP_005757699.1 NZ_LR134298:550207-550533 [Pasteurella multocida subsp. gallicida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References