Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2387542..2388180 Replicon chromosome
Accession NZ_LR134296
Organism Escherichia coli strain NCTC9041

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL151_RS11555 Protein ID WP_000813794.1
Coordinates 2388004..2388180 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL151_RS11550 Protein ID WP_001270286.1
Coordinates 2387542..2387958 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL151_RS11530 2382694..2383635 - 942 WP_001251304.1 ABC transporter permease -
EL151_RS11535 2383636..2384649 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
EL151_RS11540 2384667..2385812 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EL151_RS11545 2386057..2387463 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL151_RS11550 2387542..2387958 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL151_RS11555 2388004..2388180 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL151_RS11560 2388402..2388632 + 231 WP_000494244.1 YncJ family protein -
EL151_RS11565 2388724..2390685 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL151_RS11570 2390758..2391294 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
EL151_RS11575 2391347..2392561 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2392601..2393749 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287495 WP_000813794.1 NZ_LR134296:c2388180-2388004 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287495 WP_001270286.1 NZ_LR134296:c2387958-2387542 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References