Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1171151..1171663 Replicon chromosome
Accession NZ_LR134285
Organism Streptococcus australis strain NCTC3168

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EL100_RS05670 Protein ID WP_126404733.1
Coordinates 1171409..1171663 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EL100_RS05665 Protein ID WP_003014291.1
Coordinates 1171151..1171405 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL100_RS05630 1166326..1166637 + 312 WP_006595720.1 ribosome assembly RNA-binding protein YhbY -
EL100_RS05635 1166659..1167288 + 630 WP_126404740.1 nicotinate-nucleotide adenylyltransferase -
EL100_RS05640 1167288..1167884 + 597 WP_126404739.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EL100_RS05645 1167885..1168385 + 501 WP_126404738.1 cysteine hydrolase -
EL100_RS05650 1168400..1168753 + 354 WP_126404737.1 ribosome silencing factor -
EL100_RS05655 1169007..1169816 + 810 WP_126404735.1 class I SAM-dependent methyltransferase -
EL100_RS05660 1169823..1170917 + 1095 WP_126404734.1 nucleotidyltransferase -
EL100_RS05665 1171151..1171405 + 255 WP_003014291.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL100_RS05670 1171409..1171663 + 255 WP_126404733.1 Txe/YoeB family addiction module toxin Toxin
EL100_RS05675 1171837..1172553 + 717 WP_126404732.1 YebC/PmpR family DNA-binding transcriptional regulator -
EL100_RS05680 1172742..1173884 + 1143 WP_126404731.1 amidohydrolase -
EL100_RS05685 1174011..1174838 + 828 WP_126404730.1 amino acid ABC transporter substrate-binding protein -
EL100_RS05690 1174871..1175743 + 873 WP_126404729.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10054.53 Da        Isoelectric Point: 7.9774

>T287455 WP_126404733.1 NZ_LR134285:1171409-1171663 [Streptococcus australis]
MLLKFTEDAWKDYCYWQSQDKKTLKRINTLIKEIQKDPFAGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDESGVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9703.98 Da        Isoelectric Point: 4.6768

>AT287455 WP_003014291.1 NZ_LR134285:1171151-1171405 [Streptococcus australis]
MEAVVYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVISKSEWDSLQETLRLAQNKELSDKVLRGMAEVRAGQVQLH
EIEG

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References