Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4743812..4744587 Replicon chromosome
Accession NZ_LR134280
Organism Klebsiella pneumoniae strain NCTC9793

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag EL169_RS23785 Protein ID WP_009308645.1
Coordinates 4744102..4744587 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag EL169_RS23780 Protein ID WP_004150912.1
Coordinates 4743812..4744105 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL169_RS23760 4739020..4739622 - 603 WP_032448122.1 short chain dehydrogenase -
EL169_RS23765 4739720..4740631 + 912 WP_004181308.1 LysR family transcriptional regulator -
EL169_RS23770 4740632..4741780 - 1149 WP_040236164.1 PLP-dependent aspartate aminotransferase family protein -
EL169_RS23775 4741791..4743167 - 1377 WP_072269297.1 cystathionine beta-synthase -
EL169_RS23780 4743812..4744105 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
EL169_RS23785 4744102..4744587 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
EL169_RS23790 4745291..4745884 + 594 WP_004188553.1 hypothetical protein -
EL169_RS23795 4745981..4746197 + 217 Protein_4460 transposase -
EL169_RS23805 4746804..4747676 + 873 WP_040236165.1 ParA family protein -
EL169_RS23810 4747676..4748059 + 384 WP_040236166.1 hypothetical protein -
EL169_RS23815 4748052..4749419 + 1368 WP_040236167.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4745981..4746133 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T287452 WP_009308645.1 NZ_LR134280:4744102-4744587 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT287452 WP_004150912.1 NZ_LR134280:4743812-4744105 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References