287438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2582938..2583461 Replicon chromosome
Accession NZ_LR134271
Organism Staphylococcus aureus strain NCTC7988

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EL099_RS13470 Protein ID WP_000074048.1
Coordinates 2582938..2583204 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag EL099_RS13475 Protein ID WP_000587617.1
Coordinates 2583204..2583461 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL099_RS13450 2578148..2579335 - 1188 WP_070040315.1 MFS transporter -
EL099_RS13455 2579730..2580506 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
EL099_RS13460 2580499..2581161 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
EL099_RS13465 2581506..2582582 - 1077 WP_001076674.1 M42 family metallopeptidase -
EL099_RS13470 2582938..2583204 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EL099_RS13475 2583204..2583461 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL099_RS13485 2583822..2584277 + 456 WP_000732082.1 DUF1307 domain-containing protein -
EL099_RS13490 2584445..2586022 - 1578 WP_065315873.1 FMN-binding glutamate synthase family protein -
EL099_RS13495 2586216..2586965 + 750 WP_126525441.1 hypothetical protein -
EL099_RS13500 2587189..2588382 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T287438 WP_000074048.1 NZ_LR134271:c2583204-2582938 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT287438 WP_000587617.1 NZ_LR134271:c2583461-2583204 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References