Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2525997..2526514 Replicon chromosome
Accession NZ_LR134271
Organism Staphylococcus aureus strain NCTC7988

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EL099_RS13170 Protein ID WP_000375483.1
Coordinates 2525997..2526263 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EL099_RS13175 Protein ID WP_000584499.1
Coordinates 2526263..2526514 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL099_RS13145 2521145..2521681 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
EL099_RS13150 2522201..2523025 - 825 WP_000594631.1 formate/nitrite transporter family protein -
EL099_RS13155 2523228..2523410 - 183 WP_000079140.1 hypothetical protein -
EL099_RS13160 2523497..2523964 - 468 WP_000153340.1 SRPBCC domain-containing protein -
EL099_RS13165 2524150..2525703 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EL099_RS13170 2525997..2526263 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
EL099_RS13175 2526263..2526514 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL099_RS13180 2526678..2526778 - 101 Protein_2444 hypothetical protein -
EL099_RS13185 2526785..2527384 - 600 WP_000162810.1 DsbA family protein -
EL099_RS13190 2527403..2527765 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EL099_RS13195 2528020..2529270 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
EL099_RS13200 2529363..2530094 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EL099_RS13205 2530091..2530810 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T287436 WP_000375483.1 NZ_LR134271:c2526263-2525997 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT287436 WP_000584499.1 NZ_LR134271:c2526514-2526263 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References