Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2455021..2455583 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name higB Uniprot ID A0A7U9DG24
Locus tag EL146_RS12050 Protein ID WP_016248700.1
Coordinates 2455021..2455299 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag EL146_RS12055 Protein ID WP_000781370.1
Coordinates 2455299..2455583 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS12020 2450640..2451071 - 432 WP_000152293.1 peroxiredoxin OsmC -
EL146_RS12025 2451395..2451610 + 216 WP_000495761.1 biofilm-dependent modulation protein -
EL146_RS12030 2451701..2451838 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
EL146_RS12035 2451994..2453691 + 1698 WP_001516384.1 malate dehydrogenase -
EL146_RS12040 2453825..2454835 + 1011 WP_126511270.1 alcohol dehydrogenase AdhP -
EL146_RS12050 2455021..2455299 + 279 WP_016248700.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL146_RS12055 2455299..2455583 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
EL146_RS12060 2455811..2456464 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
EL146_RS12065 2456457..2457341 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
EL146_RS12070 2457354..2460401 - 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10623.19 Da        Isoelectric Point: 6.8682

>T287421 WP_016248700.1 NZ_LR134270:2455021-2455299 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDEIWTISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT287421 WP_000781370.1 NZ_LR134270:2455299-2455583 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DG24

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References