Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 802472..802730 Replicon chromosome
Accession NZ_LR134270
Organism Escherichia marmotae strain NCTC8196

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EL146_RS03915 Protein ID WP_000809168.1
Coordinates 802472..802624 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 802673..802730 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL146_RS03890 797797..798363 - 567 WP_000528538.1 acetate uptake transporter -
EL146_RS03900 798646..798855 - 210 WP_000843573.1 DUF2541 family protein -
EL146_RS03905 799232..801148 + 1917 WP_000516135.1 molecular chaperone DnaK -
EL146_RS03910 801237..802367 + 1131 WP_001118463.1 molecular chaperone DnaJ -
EL146_RS03915 802472..802624 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 802673..802730 + 58 - - Antitoxin
EL146_RS03920 803208..804374 + 1167 WP_000681378.1 Na+/H+ antiporter NhaA -
EL146_RS03925 804434..805339 + 906 WP_000062876.1 transcriptional activator NhaR -
EL146_RS03930 805442..805705 - 264 WP_001274018.1 30S ribosomal protein S20 -
EL146_RS03935 805808..806026 + 219 Protein_743 DUF2575 domain-containing protein -
EL146_RS03940 806034..806975 + 942 WP_000767344.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T287414 WP_000809168.1 NZ_LR134270:c802624-802472 [Escherichia marmotae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT287414 NZ_LR134270:802673-802730 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References