Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 496331..496844 Replicon chromosome
Accession NZ_LR134265
Organism Streptococcus agalactiae strain NCTC8184

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EL071_RS02590 Protein ID WP_000481712.1
Coordinates 496331..496585 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EL071_RS02595 Protein ID WP_000387490.1
Coordinates 496578..496844 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL071_RS02570 492095..494596 - 2502 WP_000239414.1 ATP-binding protein -
EL071_RS02575 494617..495027 - 411 WP_000390747.1 conjugal transfer protein -
EL071_RS02580 495038..495304 - 267 WP_001055037.1 hypothetical protein -
EL071_RS02585 495325..496278 - 954 WP_000565540.1 conjugal transfer protein -
EL071_RS02590 496331..496585 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EL071_RS02595 496578..496844 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EL071_RS02600 496989..497462 - 474 WP_000560386.1 hypothetical protein -
EL071_RS02605 497470..497952 - 483 WP_000383283.1 antirestriction protein ArdA -
EL071_RS02610 498005..498277 - 273 WP_000017154.1 hypothetical protein -
EL071_RS02615 498412..498980 - 569 Protein_495 hypothetical protein -
EL071_RS02620 498983..500332 - 1350 WP_000491712.1 AAA family ATPase -
EL071_RS02625 500529..500828 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
EL071_RS02630 500812..501189 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb / cfa/cfb / groEL 492262..580169 87907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T287400 WP_000481712.1 NZ_LR134265:c496585-496331 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT287400 WP_000387490.1 NZ_LR134265:c496844-496578 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References