Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3721720..3722261 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag EL129_RS18300 Protein ID WP_000615983.1
Coordinates 3721983..3722261 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag EL129_RS18295 Protein ID WP_000729703.1
Coordinates 3721720..3721980 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS18275 3717395..3718180 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
EL129_RS18280 3718152..3719864 + 1713 Protein_3537 flagellar biosynthesis protein FlhA -
EL129_RS18285 3720088..3720585 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
EL129_RS18290 3720761..3721510 - 750 WP_024192679.1 C40 family peptidase -
EL129_RS18295 3721720..3721980 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL129_RS18300 3721983..3722261 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL129_RS18305 3722417..3723157 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL129_RS18310 3723128..3723895 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL129_RS18315 3724101..3724679 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3714561..3730804 16243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T287339 WP_000615983.1 NZ_LR134240:3721983-3722261 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT287339 WP_000729703.1 NZ_LR134240:3721720-3721980 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References