Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1811691..1812193 Replicon chromosome
Accession NZ_LR134240
Organism Escherichia coli strain NCTC9107

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL129_RS08665 Protein ID WP_000767829.1
Coordinates 1811939..1812193 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL129_RS08660 Protein ID WP_001259255.1
Coordinates 1811691..1811942 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL129_RS08635 1806869..1807936 - 1068 WP_032208185.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL129_RS08640 1807936..1809006 - 1071 WP_032208187.1 histidinol-phosphate transaminase -
EL129_RS08645 1809003..1810307 - 1305 WP_021569431.1 histidinol dehydrogenase -
EL129_RS08650 1810313..1811212 - 900 WP_000131776.1 ATP phosphoribosyltransferase -
EL129_RS08655 1811358..1811408 - 51 WP_001364200.1 his operon leader peptide -
EL129_RS08660 1811691..1811942 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL129_RS08665 1811939..1812193 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL129_RS08670 1812276..1813100 + 825 WP_021569430.1 SDR family oxidoreductase -
EL129_RS08675 1813146..1814075 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL129_RS08680 1814290..1814352 + 63 WP_010723108.1 membrane protein YoeI -
EL129_RS08685 1814342..1815700 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL129_RS08690 1815879..1816937 + 1059 WP_000492312.1 transport protein YeeE -
EL129_RS08695 1816951..1817178 + 228 WP_021569429.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287329 WP_000767829.1 NZ_LR134240:1811939-1812193 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287329 WP_001259255.1 NZ_LR134240:1811691-1811942 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References