Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1778852..1779354 Replicon chromosome
Accession NZ_LR134239
Organism Escherichia coli strain NCTC9100

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EL124_RS08475 Protein ID WP_001471733.1
Coordinates 1779100..1779354 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL124_RS08470 Protein ID WP_001259255.1
Coordinates 1778852..1779103 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL124_RS08440 1774030..1775097 - 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL124_RS08445 1775097..1776167 - 1071 WP_001374029.1 histidinol-phosphate transaminase -
EL124_RS08450 1776164..1777468 - 1305 WP_001748534.1 histidinol dehydrogenase -
EL124_RS08455 1777474..1778373 - 900 WP_001374031.1 ATP phosphoribosyltransferase -
EL124_RS08460 1778519..1778569 - 51 WP_001364200.1 his operon leader peptide -
EL124_RS08470 1778852..1779103 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL124_RS08475 1779100..1779354 + 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL124_RS08480 1779437..1780261 + 825 WP_000754737.1 SDR family oxidoreductase -
EL124_RS08485 1780307..1781236 + 930 WP_001374016.1 LysR family transcriptional regulator -
EL124_RS08490 1781451..1781513 + 63 WP_010723108.1 membrane protein YoeI -
EL124_RS08495 1781503..1782861 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T287311 WP_001471733.1 NZ_LR134239:1779100-1779354 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287311 WP_001259255.1 NZ_LR134239:1778852-1779103 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References