Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 709436..710129 Replicon chromosome
Accession NZ_LR134239
Organism Escherichia coli strain NCTC9100

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EL124_RS03435 Protein ID WP_000415584.1
Coordinates 709436..709732 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EL124_RS03440 Protein ID WP_000650107.1
Coordinates 709734..710129 (+) Length 132 a.a.

Genomic Context

EL124_RS03410EL124_RS03425EL124_RS03430EL124_RS03435EL124_RS03440EL124_RS03445EL124_RS03450EL124_RS03400EL124_RS03405EL124_RS03415EL124_RS03420
Location: 705769..706101 (333 bp)
Type: Others
Protein ID: WP_000917684.1
Location: 708304..708696 (393 bp)
Type: Others
Protein ID: WP_000712658.1
Location: 708749..709231 (483 bp)
Type: Others
Protein ID: WP_000183505.1
Location: 709436..709732 (297 bp)
Type: Toxin
Protein ID: WP_000415584.1
Location: 709734..710129 (396 bp)
Type: Antitoxin
Protein ID: WP_000650107.1
Location: 710262..711869 (1608 bp)
Type: Others
Protein ID: WP_001295629.1
Location: 712007..714265 (2259 bp)
Type: Others
Protein ID: WP_001281881.1
Location: 704524..704838 (315 bp)
Type: Others
Protein ID: WP_000958598.1
Location: 704869..705450 (582 bp)
Type: Others
Protein ID: WP_000065430.1
Location: 706147..707496 (1350 bp)
Type: Others
Protein ID: WP_000673402.1
Location: 707493..708152 (660 bp)
Type: Others
Protein ID: WP_001221493.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL124_RS03400704524..704838-315WP_000958598.1antibiotic biosynthesis monooxygenase-
EL124_RS03405704869..705450-582WP_000065430.1NADPH:quinone oxidoreductase MdaB-
EL124_RS03410705769..706101+333WP_000917684.1DUF2645 family protein-
EL124_RS03415706147..707496-1350WP_000673402.1two-component system sensor histidine kinase QseC-
EL124_RS03420707493..708152-660WP_001221493.1two-component system response regulator QseB-
EL124_RS03425708304..708696+393WP_000712658.1OB fold stress tolerance protein YgiW-
EL124_RS03430708749..709231+483WP_000183505.1transcriptional regulator-
EL124_RS03435709436..709732+297WP_000415584.1type II toxin-antitoxin system toxin MqsRToxin
EL124_RS03440709734..710129+396WP_000650107.1type II toxin-antitoxin system antitoxin MqsAAntitoxin
EL124_RS03445710262..711869+1608WP_001295629.1ABC transporter substrate-binding protein-
EL124_RS03450712007..714265+2259WP_001281881.1DNA topoisomerase IV subunit A-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T287308 WP_000415584.1 NZ_LR134239:709436-709732 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT287308 WP_000650107.1 NZ_LR134239:709734-710129 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB3HI2

Antitoxin

Loading, please wait
Source
ID
Structure
PDB3HI2
PDB3GA8
PDB3O9X
PDB2KZ8
PDB3FMY
PDB3GN5
AlphaFold DBA0A7U9LU65

References