Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4950801..4951403 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag EL138_RS24415 Protein ID WP_000897302.1
Coordinates 4951092..4951403 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL138_RS24410 Protein ID WP_000356397.1
Coordinates 4950801..4951091 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS24375 4946874..4947776 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
EL138_RS24380 4947773..4948408 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
EL138_RS24385 4948405..4949334 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
EL138_RS24390 4949550..4949768 - 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
EL138_RS24400 4950164..4950442 - 279 WP_001296612.1 hypothetical protein -
EL138_RS24410 4950801..4951091 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EL138_RS24415 4951092..4951403 - 312 WP_000897302.1 hypothetical protein Toxin
EL138_RS24420 4951633..4952541 + 909 WP_126299519.1 alpha/beta hydrolase -
EL138_RS24425 4952605..4953546 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
EL138_RS24430 4953591..4954028 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL138_RS24435 4954025..4954897 - 873 WP_000920762.1 virulence factor BrkB family protein -
EL138_RS24440 4954891..4955490 - 600 WP_001443191.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T287305 WP_000897302.1 NZ_LR134237:c4951403-4951092 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT287305 WP_000356397.1 NZ_LR134237:c4951091-4950801 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References