Detailed information of TA system TA287299

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 4380547..4380959
• Replicon: chromosome
• Accession: NZ_LR134237
• Organism: Escherichia coli strain NCTC9022

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: EL138_RS21750
• Protein ID: WP_000132630.1
• Coordinates: 4380618..4380959 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4380547..4380623 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL138_RS21740	4377159..4378628	+	1470	WP_001315223.1	type I restriction-modification system subunit M	-
EL138_RS21745	4378628..4380397	+	1770	WP_000110076.1	restriction endonuclease subunit S	-
-	4380547..4380623	-	77	NuclAT_6	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_6	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_6	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_6	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_7	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_7	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_7	-	Antitoxin
-	4380547..4380623	-	77	NuclAT_7	-	Antitoxin
EL138_RS21750	4380618..4380959	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
EL138_RS21755	4381006..4383099	-	2094	WP_000648234.1	DUF262 domain-containing protein	-
EL138_RS21760	4383197..4383277	-	81	WP_020233658.1	hypothetical protein	-
EL138_RS21765	4383505..4384425	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
EL138_RS21770	4384610..4385890	+	1281	WP_001304526.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	4364780..4383162	18382

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T287299 WP_000132630.1 NZ_LR134237:4380618-4380959 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT287299 NZ_LR134237:c4380623-4380547 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin