Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4299322..4299580 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EL138_RS21360 Protein ID WP_000809168.1
Coordinates 4299428..4299580 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4299322..4299379 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS21345 4295151..4296410 - 1260 WP_000494928.1 hypothetical protein -
EL138_RS21350 4296539..4298032 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
EL138_RS21355 4298052..4298813 - 762 WP_001274832.1 hypothetical protein -
- 4299322..4299379 - 58 - - Antitoxin
EL138_RS21360 4299428..4299580 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
EL138_RS21365 4299685..4300815 - 1131 WP_001118464.1 molecular chaperone DnaJ -
EL138_RS21370 4300904..4302820 - 1917 WP_000516135.1 molecular chaperone DnaK -
EL138_RS21375 4303192..4303596 + 405 WP_000843687.1 DUF2541 family protein -
EL138_RS21380 4303622..4304335 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T287298 WP_000809168.1 NZ_LR134237:4299428-4299580 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT287298 NZ_LR134237:c4299379-4299322 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References