Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1987443..1987945 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag EL138_RS09635 Protein ID WP_000767823.1
Coordinates 1987691..1987945 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL138_RS09630 Protein ID WP_001259255.1
Coordinates 1987443..1987694 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS09600 1982621..1983688 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL138_RS09605 1983688..1984758 - 1071 WP_000108996.1 histidinol-phosphate transaminase -
EL138_RS09610 1984755..1986059 - 1305 WP_001297912.1 histidinol dehydrogenase -
EL138_RS09615 1986065..1986964 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL138_RS09620 1987110..1987160 - 51 WP_001364200.1 his operon leader peptide -
EL138_RS09630 1987443..1987694 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL138_RS09635 1987691..1987945 + 255 WP_000767823.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL138_RS09640 1988028..1988852 + 825 WP_000754737.1 SDR family oxidoreductase -
EL138_RS09645 1988898..1989827 + 930 WP_000803366.1 LysR family transcriptional regulator -
EL138_RS09650 1990042..1990104 + 63 WP_010723108.1 membrane protein YoeI -
EL138_RS09655 1990094..1991452 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10210.65 Da        Isoelectric Point: 8.8482

>T287287 WP_000767823.1 NZ_LR134237:1987691-1987945 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRKPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287287 WP_001259255.1 NZ_LR134237:1987443-1987694 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References