Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 621464..622263 Replicon chromosome
Accession NZ_LR134237
Organism Escherichia coli strain NCTC9022

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag EL138_RS03065 Protein ID WP_000347252.1
Coordinates 621464..621928 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag EL138_RS03070 Protein ID WP_001296435.1
Coordinates 621928..622263 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL138_RS03035 616465..616899 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL138_RS03040 616917..617795 - 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL138_RS03045 617785..618564 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL138_RS03050 618575..619048 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL138_RS03055 619071..620351 - 1281 WP_000681926.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL138_RS03060 620600..621409 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EL138_RS03065 621464..621928 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL138_RS03070 621928..622263 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL138_RS03075 622412..623983 - 1572 WP_001273940.1 galactarate dehydratase -
EL138_RS03080 624358..625692 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
EL138_RS03085 625708..626478 + 771 WP_001058223.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T287284 WP_000347252.1 NZ_LR134237:c621928-621464 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT287284 WP_001296435.1 NZ_LR134237:c622263-621928 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References