287266

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1858883..1859385 Replicon chromosome
Accession NZ_LR134236
Organism Escherichia coli strain NCTC9008

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL127_RS08870 Protein ID WP_000767829.1
Coordinates 1859131..1859385 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL127_RS08865 Protein ID WP_001259255.1
Coordinates 1858883..1859134 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL127_RS08840 1854061..1855128 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL127_RS08845 1855128..1856198 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
EL127_RS08850 1856195..1857499 - 1305 WP_001515511.1 histidinol dehydrogenase -
EL127_RS08855 1857505..1858404 - 900 WP_000131776.1 ATP phosphoribosyltransferase -
EL127_RS08860 1858550..1858600 - 51 WP_001364200.1 his operon leader peptide -
EL127_RS08865 1858883..1859134 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL127_RS08870 1859131..1859385 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL127_RS08875 1859468..1860292 + 825 WP_000754749.1 SDR family oxidoreductase -
EL127_RS08880 1860338..1861267 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL127_RS08885 1861482..1861544 + 63 WP_010723108.1 membrane protein YoeI -
EL127_RS08890 1861534..1862892 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL127_RS08895 1863071..1864129 + 1059 WP_000492315.1 transport protein YeeE -
EL127_RS08900 1864143..1864370 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287266 WP_000767829.1 NZ_LR134236:1859131-1859385 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287266 WP_001259255.1 NZ_LR134236:1858883-1859134 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References