287262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 716488..717181 Replicon chromosome
Accession NZ_LR134236
Organism Escherichia coli strain NCTC9008

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EL127_RS03510 Protein ID WP_000415584.1
Coordinates 716488..716784 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EL127_RS03515 Protein ID WP_000650107.1
Coordinates 716786..717181 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL127_RS03475 711576..711890 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
EL127_RS03480 711921..712502 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EL127_RS03485 712821..713153 + 333 WP_000917684.1 DUF2645 family protein -
EL127_RS03490 713199..714548 - 1350 WP_000673399.1 two-component system sensor histidine kinase QseC -
EL127_RS03495 714545..715204 - 660 WP_126496922.1 two-component system response regulator QseB -
EL127_RS03500 715356..715748 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EL127_RS03505 715801..716283 + 483 WP_000183505.1 transcriptional regulator -
EL127_RS03510 716488..716784 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EL127_RS03515 716786..717181 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EL127_RS03520 717314..718924 + 1611 WP_126496923.1 ABC transporter substrate-binding protein -
EL127_RS03525 719062..721320 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T287262 WP_000415584.1 NZ_LR134236:716488-716784 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT287262 WP_000650107.1 NZ_LR134236:716786-717181 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References