Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2993157..2993803 Replicon chromosome
Accession NZ_LR134235
Organism Klebsiella variicola strain NCTC9668

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EL159_RS14800 Protein ID WP_063105971.1
Coordinates 2993157..2993504 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag EL159_RS14805 Protein ID WP_008806992.1
Coordinates 2993504..2993803 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL159_RS14790 2989044..2990477 + 1434 WP_004202133.1 glycogen synthase GlgA -
EL159_RS14795 2990495..2992942 + 2448 WP_008806990.1 glycogen phosphorylase -
EL159_RS14800 2993157..2993504 + 348 WP_063105971.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL159_RS14805 2993504..2993803 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
EL159_RS14810 2993866..2995374 - 1509 WP_004202136.1 glycerol-3-phosphate dehydrogenase -
EL159_RS14815 2995579..2995908 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
EL159_RS14820 2995959..2996789 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
EL159_RS14825 2996839..2997598 + 760 Protein_2787 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13476.47 Da        Isoelectric Point: 6.2327

>T287253 WP_063105971.1 NZ_LR134235:2993157-2993504 [Klebsiella variicola]
MWDAETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT287253 WP_008806992.1 NZ_LR134235:2993504-2993803 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References