Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4252168..4252709 Replicon chromosome
Accession NZ_LR134234
Organism Escherichia coli strain NCTC8623

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag EL131_RS20765 Protein ID WP_000615979.1
Coordinates 4252168..4252446 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EL131_RS20770 Protein ID WP_000729704.1
Coordinates 4252449..4252709 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL131_RS20750 4249750..4250328 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
EL131_RS20755 4250534..4251301 + 768 WP_000333380.1 class II glutamine amidotransferase -
EL131_RS20760 4251272..4252012 - 741 WP_001225679.1 murein L,D-transpeptidase -
EL131_RS20765 4252168..4252446 - 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL131_RS20770 4252449..4252709 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL131_RS20775 4252895..4253668 + 774 WP_000543899.1 C40 family peptidase -
EL131_RS20780 4253725..4254081 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
EL131_RS20785 4254074..4254352 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EL131_RS20790 4254457..4256169 - 1713 Protein_4009 flagellar biosynthesis protein FlhA -
EL131_RS20795 4256141..4256926 + 786 WP_000207589.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T287244 WP_000615979.1 NZ_LR134234:c4252446-4252168 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT287244 WP_000729704.1 NZ_LR134234:c4252709-4252449 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References