Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3580691..3581232 Replicon chromosome
Accession NZ_LR134231
Organism Escherichia coli strain NCTC9087

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag EL105_RS17480 Protein ID WP_000615983.1
Coordinates 3580954..3581232 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag EL105_RS17475 Protein ID WP_000729703.1
Coordinates 3580691..3580951 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL105_RS17455 3576366..3577151 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
EL105_RS17460 3577123..3578835 + 1713 Protein_3397 flagellar biosynthesis protein FlhA -
EL105_RS17465 3579059..3579556 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
EL105_RS17470 3579732..3580481 - 750 WP_000056849.1 C40 family peptidase -
EL105_RS17475 3580691..3580951 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL105_RS17480 3580954..3581232 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL105_RS17485 3581388..3582128 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL105_RS17490 3582099..3582866 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL105_RS17495 3583072..3583650 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagW/ecpD / yagV/ecpE / gmhA/lpcA / rhs/PAAR / rhs/PAAR / tssA / hcp1/tssD1 3532130..3602708 70578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T287222 WP_000615983.1 NZ_LR134231:3580954-3581232 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT287222 WP_000729703.1 NZ_LR134231:3580691-3580951 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References