Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1751063..1751565 Replicon chromosome
Accession NZ_LR134231
Organism Escherichia coli strain NCTC9087

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL105_RS08340 Protein ID WP_000767829.1
Coordinates 1751311..1751565 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL105_RS08335 Protein ID WP_001259255.1
Coordinates 1751063..1751314 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL105_RS08310 1746241..1747308 - 1068 WP_126496323.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL105_RS08315 1747308..1748378 - 1071 WP_021578586.1 histidinol-phosphate transaminase -
EL105_RS08320 1748375..1749679 - 1305 WP_052904472.1 histidinol dehydrogenase -
EL105_RS08325 1749685..1750584 - 900 WP_000131783.1 ATP phosphoribosyltransferase -
EL105_RS08330 1750730..1750780 - 51 WP_001364200.1 his operon leader peptide -
EL105_RS08335 1751063..1751314 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL105_RS08340 1751311..1751565 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL105_RS08345 1751648..1752472 + 825 WP_000754758.1 SDR family oxidoreductase -
EL105_RS08350 1752518..1753447 + 930 WP_000803351.1 LysR family transcriptional regulator -
EL105_RS08355 1753662..1753724 + 63 WP_010723108.1 membrane protein YoeI -
EL105_RS08360 1753714..1755072 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL105_RS08365 1755251..1756309 + 1059 WP_000492310.1 transport protein YeeE -
EL105_RS08370 1756323..1756550 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287212 WP_000767829.1 NZ_LR134231:1751311-1751565 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287212 WP_001259255.1 NZ_LR134231:1751063-1751314 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References