Detailed information of TA system TA287205

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4215026..4215438
• Replicon: chromosome
• Accession: NZ_LR134228
• Organism: Escherichia coli strain NCTC9699

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: EL118_RS20475
• Protein ID: WP_000132601.1
• Coordinates: 4215097..4215438 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4215026..4215102 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL118_RS20465	4211889..4213478	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
EL118_RS20470	4213475..4214869	+	1395	WP_126509295.1	type I restriction-modification system specificity subunit	-
-	4215026..4215102	-	77	NuclAT_13	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_13	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_13	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_13	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_14	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_14	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_14	-	Antitoxin
-	4215026..4215102	-	77	NuclAT_14	-	Antitoxin
EL118_RS20475	4215097..4215438	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
EL118_RS20480	4215600..4216979	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
EL118_RS20485	4216979..4218025	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T287205 WP_000132601.1 NZ_LR134228:4215097-4215438 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT287205 NZ_LR134228:c4215102-4215026 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin