Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1909945..1910447 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL118_RS09140 Protein ID WP_000767829.1
Coordinates 1910193..1910447 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL118_RS09135 Protein ID WP_001259255.1
Coordinates 1909945..1910196 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS09110 1905126..1906193 - 1068 WP_021579314.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL118_RS09115 1906190..1907260 - 1071 WP_001572811.1 histidinol-phosphate transaminase -
EL118_RS09120 1907257..1908561 - 1305 WP_001572810.1 histidinol dehydrogenase -
EL118_RS09125 1908567..1909466 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL118_RS09130 1909612..1909662 - 51 WP_001364200.1 his operon leader peptide -
EL118_RS09135 1909945..1910196 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL118_RS09140 1910193..1910447 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL118_RS09145 1910530..1911354 + 825 WP_000754737.1 SDR family oxidoreductase -
EL118_RS09150 1911400..1912329 + 930 WP_000803360.1 LysR family transcriptional regulator -
EL118_RS09155 1912544..1912606 + 63 WP_010723108.1 membrane protein YoeI -
EL118_RS09160 1912596..1913954 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL118_RS09165 1914063..1914760 + 698 Protein_1775 IS1 family transposase -
EL118_RS09170 1914770..1914937 + 168 WP_126509182.1 DUF987 family protein -
EL118_RS09175 1915011..1915379 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1914257..1914760 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287194 WP_000767829.1 NZ_LR134228:1910193-1910447 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287194 WP_001259255.1 NZ_LR134228:1909945-1910196 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References