Detailed information of TA system TA287180

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 3877690..3878102
• Replicon: chromosome
• Accession: NZ_LR134227
• Organism: Escherichia coli strain NCTC9102

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: EL093_RS18895
• Protein ID: WP_000132601.1
• Coordinates: 3877761..3878102 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	3877690..3877766 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL093_RS18885	3874553..3876142	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
EL093_RS18890	3876139..3877533	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	3877690..3877766	-	77	NuclAT_11	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_11	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_11	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_11	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_12	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_12	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_12	-	Antitoxin
-	3877690..3877766	-	77	NuclAT_12	-	Antitoxin
EL093_RS18895	3877761..3878102	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
EL093_RS18900	3878264..3879643	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
EL093_RS18905	3879643..3880689	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3876139..3891056	14917

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T287180 WP_000132601.1 NZ_LR134227:3877761-3878102 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T287180 NZ_LR134227:3877761-3878102 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT287180 NZ_LR134227:c3877766-3877690 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin