Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1766850..1767352 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL093_RS08470 Protein ID WP_000767829.1
Coordinates 1767098..1767352 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL093_RS08465 Protein ID WP_001259255.1
Coordinates 1766850..1767101 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS08440 1762027..1763094 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL093_RS08445 1763094..1764164 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
EL093_RS08450 1764161..1765465 - 1305 WP_021499265.1 histidinol dehydrogenase -
EL093_RS08455 1765471..1766370 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL093_RS08460 1766516..1766566 - 51 WP_001364200.1 his operon leader peptide -
EL093_RS08465 1766850..1767101 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL093_RS08470 1767098..1767352 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL093_RS08475 1767435..1768259 + 825 WP_000754737.1 SDR family oxidoreductase -
EL093_RS08480 1768305..1769234 + 930 WP_000803366.1 LysR family transcriptional regulator -
EL093_RS08485 1769449..1769511 + 63 WP_010723108.1 membrane protein YoeI -
EL093_RS08490 1769501..1770859 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL093_RS08495 1771038..1772096 + 1059 WP_023568405.1 transport protein YeeE -
EL093_RS08500 1772110..1772337 + 228 WP_000985278.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287169 WP_000767829.1 NZ_LR134227:1767098-1767352 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287169 WP_001259255.1 NZ_LR134227:1766850-1767101 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References