287169

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1766850..1767352 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL093_RS08470 Protein ID WP_000767829.1
Coordinates 1767098..1767352 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL093_RS08465 Protein ID WP_001259255.1
Coordinates 1766850..1767101 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS08440 1762027..1763094 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL093_RS08445 1763094..1764164 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
EL093_RS08450 1764161..1765465 - 1305 WP_021499265.1 histidinol dehydrogenase -
EL093_RS08455 1765471..1766370 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL093_RS08460 1766516..1766566 - 51 WP_001364200.1 his operon leader peptide -
EL093_RS08465 1766850..1767101 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL093_RS08470 1767098..1767352 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL093_RS08475 1767435..1768259 + 825 WP_000754737.1 SDR family oxidoreductase -
EL093_RS08480 1768305..1769234 + 930 WP_000803366.1 LysR family transcriptional regulator -
EL093_RS08485 1769449..1769511 + 63 WP_010723108.1 membrane protein YoeI -
EL093_RS08490 1769501..1770859 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL093_RS08495 1771038..1772096 + 1059 WP_023568405.1 transport protein YeeE -
EL093_RS08500 1772110..1772337 + 228 WP_000985278.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287169 WP_000767829.1 NZ_LR134227:1767098-1767352 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287169 WP_001259255.1 NZ_LR134227:1766850-1767101 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References