Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4530528..4531130 Replicon chromosome
Accession NZ_LR134226
Organism Escherichia coli strain NCTC9088

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag EL094_RS21925 Protein ID WP_000897305.1
Coordinates 4530819..4531130 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EL094_RS21920 Protein ID WP_000356397.1
Coordinates 4530528..4530818 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL094_RS21895 4526454..4527356 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
EL094_RS21900 4527353..4527988 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
EL094_RS21905 4527985..4528914 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
EL094_RS21910 4529244..4529486 - 243 WP_001086388.1 hypothetical protein -
EL094_RS21915 4529705..4529923 - 219 WP_001297075.1 ribbon-helix-helix domain-containing protein -
EL094_RS21920 4530528..4530818 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EL094_RS21925 4530819..4531130 - 312 WP_000897305.1 hypothetical protein Toxin
EL094_RS21930 4531359..4532267 + 909 WP_001162704.1 alpha/beta hydrolase -
EL094_RS21935 4532331..4533272 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
EL094_RS21940 4533317..4533754 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL094_RS21945 4533751..4534623 - 873 WP_000920762.1 virulence factor BrkB family protein -
EL094_RS21950 4534617..4535216 - 600 WP_001295269.1 glucose-1-phosphatase -
EL094_RS21955 4535315..4536100 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T287162 WP_000897305.1 NZ_LR134226:c4531130-4530819 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT287162 WP_000356397.1 NZ_LR134226:c4530818-4530528 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References