287159

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3694592..3695133 Replicon chromosome
Accession NZ_LR134226
Organism Escherichia coli strain NCTC9088

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag EL094_RS18070 Protein ID WP_000615979.1
Coordinates 3694855..3695133 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EL094_RS18065 Protein ID WP_000729704.1
Coordinates 3694592..3694852 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL094_RS18040 3690375..3691160 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
EL094_RS18045 3691132..3692844 + 1713 Protein_3485 flagellar biosynthesis protein FlhA -
EL094_RS18050 3692949..3693227 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
EL094_RS18055 3693220..3693576 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
EL094_RS18060 3693633..3694406 - 774 WP_000543899.1 C40 family peptidase -
EL094_RS18065 3694592..3694852 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EL094_RS18070 3694855..3695133 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EL094_RS18075 3695289..3696029 + 741 WP_001225679.1 murein L,D-transpeptidase -
EL094_RS18080 3696000..3696767 - 768 WP_000333380.1 class II glutamine amidotransferase -
EL094_RS18085 3696973..3697551 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3693220..3711120 17900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T287159 WP_000615979.1 NZ_LR134226:3694855-3695133 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT287159 WP_000729704.1 NZ_LR134226:3694592-3694852 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References