Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1779263..1779765 Replicon chromosome
Accession NZ_LR134226
Organism Escherichia coli strain NCTC9088

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL094_RS08575 Protein ID WP_000767829.1
Coordinates 1779511..1779765 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL094_RS08570 Protein ID WP_001259255.1
Coordinates 1779263..1779514 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL094_RS08545 1774441..1775508 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL094_RS08550 1775508..1776578 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
EL094_RS08555 1776575..1777879 - 1305 WP_001593467.1 histidinol dehydrogenase -
EL094_RS08560 1777885..1778784 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL094_RS08565 1778930..1778980 - 51 WP_001364200.1 his operon leader peptide -
EL094_RS08570 1779263..1779514 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL094_RS08575 1779511..1779765 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL094_RS08580 1779848..1780672 + 825 WP_000754758.1 SDR family oxidoreductase -
EL094_RS08585 1780718..1781647 + 930 WP_000803370.1 LysR family transcriptional regulator -
EL094_RS08590 1781862..1781924 + 63 WP_010723108.1 membrane protein YoeI -
EL094_RS08595 1781914..1783272 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL094_RS08600 1783451..1784509 + 1059 WP_000492346.1 transport protein YeeE -
EL094_RS08605 1784523..1784750 + 228 WP_000985270.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287151 WP_000767829.1 NZ_LR134226:1779511-1779765 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287151 WP_001259255.1 NZ_LR134226:1779263-1779514 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References