Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 593677..594476 Replicon chromosome
Accession NZ_LR134226
Organism Escherichia coli strain NCTC9088

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag EL094_RS02955 Protein ID WP_126322044.1
Coordinates 593677..594141 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EL094_RS02960 Protein ID WP_001307405.1
Coordinates 594141..594476 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL094_RS02925 588678..589112 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL094_RS02930 589130..590008 - 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL094_RS02935 589998..590777 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL094_RS02940 590788..591261 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL094_RS02945 591284..592564 - 1281 WP_000681922.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL094_RS02950 592813..593622 + 810 WP_000072193.1 aga operon transcriptional regulator AgaR -
EL094_RS02955 593677..594141 - 465 WP_126322044.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL094_RS02960 594141..594476 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL094_RS02965 594625..596196 - 1572 WP_001273741.1 galactarate dehydratase -
EL094_RS02970 596571..597905 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
EL094_RS02975 597921..598691 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 593677..605352 11675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17823.21 Da        Isoelectric Point: 9.4947

>T287147 WP_126322044.1 NZ_LR134226:c594141-593677 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHLPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT287147 WP_001307405.1 NZ_LR134226:c594476-594141 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References