Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1819712..1820214 Replicon chromosome
Accession NZ_LR134222
Organism Escherichia coli strain NCTC11129

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EL113_RS08790 Protein ID WP_000767829.1
Coordinates 1819960..1820214 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EL113_RS08785 Protein ID WP_001259255.1
Coordinates 1819712..1819963 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL113_RS08760 1814890..1815957 - 1068 WP_032248774.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EL113_RS08765 1815957..1817027 - 1071 WP_032248775.1 histidinol-phosphate transaminase -
EL113_RS08770 1817024..1818328 - 1305 WP_001572810.1 histidinol dehydrogenase -
EL113_RS08775 1818334..1819233 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EL113_RS08780 1819379..1819429 - 51 WP_001364200.1 his operon leader peptide -
EL113_RS08785 1819712..1819963 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EL113_RS08790 1819960..1820214 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EL113_RS08795 1820297..1821121 + 825 WP_000754737.1 SDR family oxidoreductase -
EL113_RS08800 1821167..1822096 + 930 WP_000803360.1 LysR family transcriptional regulator -
EL113_RS08805 1822311..1822373 + 63 WP_010723108.1 membrane protein YoeI -
EL113_RS08810 1822363..1823721 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EL113_RS08815 1823900..1824958 + 1059 WP_034169328.1 transport protein YeeE -
EL113_RS08820 1824972..1825199 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T287126 WP_000767829.1 NZ_LR134222:1819960-1820214 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT287126 WP_001259255.1 NZ_LR134222:1819712-1819963 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References