287119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3702907..3703601 Replicon chromosome
Accession NZ_LR134220
Organism Escherichia coli strain NCTC11121

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag EL088_RS18225 Protein ID WP_001263493.1
Coordinates 3702907..3703305 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag EL088_RS18230 Protein ID WP_000554757.1
Coordinates 3703308..3703601 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- 3698566..3698646 - 81 NuclAT_8 - -
- 3698566..3698646 - 81 NuclAT_8 - -
- 3698566..3698646 - 81 NuclAT_8 - -
- 3698566..3698646 - 81 NuclAT_8 - -
EL088_RS18200 3699242..3699700 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
EL088_RS18205 3699961..3701418 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
EL088_RS18210 3701475..3701996 - 522 Protein_3542 peptide chain release factor H -
EL088_RS18215 3701995..3702198 - 204 Protein_3543 RNA ligase RtcB family protein -
EL088_RS18220 3702445..3702897 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
EL088_RS18225 3702907..3703305 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
EL088_RS18230 3703308..3703601 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
EL088_RS18235 3703653..3704708 - 1056 WP_111724751.1 DNA polymerase IV -
EL088_RS18240 3704779..3705564 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
EL088_RS18245 3705536..3707248 + 1713 Protein_3549 flagellar biosynthesis protein FlhA -
EL088_RS18250 3707464..3707961 - 498 WP_000006256.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T287119 WP_001263493.1 NZ_LR134220:c3703305-3702907 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT287119 WP_000554757.1 NZ_LR134220:c3703601-3703308 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EXB8

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References